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Oxyfedrine in myocardial stunning
S K Maulik1, S D Seth, M Maulik
1Department of Pharmacology, All India Institute of Medical Sciences, New Delhi, India.
Indian Journal of Experimental Biology
|May 6, 1998
Abstract:
Effect of oxyfedrine (OXF)(1 mg/kg) administered just before reperfusion (post-treatment) was investigated in a canine model of myocardial stunning. In the saline-treated animals, myocardial stunning was evidenced by fall in MAP, decrease in LV peak (+) dP/dt, rise in LVEDP and incomplete regeneration of myocardial ATP, after reperfusion. OXF was found to be effective in preventing the haemodynamic and metabolic changes associated with myocardial stunning.