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Related Experiment Videos

Gemfibrozil-induced decrease in serum ubiquinone and alpha- and gamma-tocopherol levels in men with combined

F Aberg1, E L Appelkvist, A Bröijersén

  • 1Clinical Research Center, Novum, Sweden.

European Journal of Clinical Investigation
|May 6, 1998
PubMed
Summary
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Gemfibrozil treatment significantly reduced serum antioxidant levels, including ubiquinone-10, alpha-tocopherol, and gamma-tocopherol, in men with hyperlipidaemia. These antioxidant levels decreased to those observed in healthy individuals.

Area of Science:

  • Biochemistry
  • Cardiovascular Medicine
  • Nutritional Science

Background:

  • Low blood antioxidant levels are linked to increased coronary artery disease risk.
  • Lipophilic antioxidants are transported via lipoproteins, potentially affected by hypolipidaemic therapies.

Purpose of the Study:

  • To investigate the effect of gemfibrozil treatment on serum concentrations of ubiquinone-10, alpha-tocopherol, and gamma-tocopherol in men with combined hyperlipidaemia.

Main Methods:

  • A randomized, placebo-controlled, cross-over study involving 21 men with combined hyperlipidaemia.
  • Participants received gemfibrozil treatment for 10-12 weeks.

Main Results:

  • Gemfibrozil significantly reduced triglycerides, total cholesterol, and VLDL-cholesterol, while increasing HDL-cholesterol.

Related Experiment Videos

  • Serum levels of ubiquinone-10, alpha-tocopherol, and gamma-tocopherol decreased significantly (P < 0.001) with gemfibrozil treatment.
  • Antioxidant levels in treated patients fell to those seen in normolipidaemic controls.

    • Conclusions:

    • Gemfibrozil therapy in hyperlipidaemic men lowers serum antioxidant levels.
    • The clinical significance and underlying mechanisms of this reduction require further investigation.