Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Interferon-alpha: evolving therapy for AIDS-associated Kaposi's sarcoma

S E Krown1

  • 1Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA. krowns@mskcc.org

Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research
|May 6, 1998
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Management of Kaposi sarcoma: the role of interferon and thalidomide.

Current opinion in oncology·2001
Same author

Phase II, randomized, open-label, community-based trial to compare the safety and activity of combination therapy with recombinant interferon-alpha2b and zidovudine versus zidovudine alone in patients with asymptomatic to mildly symptomatic HIV infection. HIV Protocol C91-253 Study Team.

Journal of acquired immune deficiency syndromes and human retrovirology : official publication of the International Retrovirology Association·1999
Same author

Clinical overview: issues in Kaposi's sarcoma therapeutics.

Journal of the National Cancer Institute. Monographs·1998
Same author

Phase I/II trial of the type I soluble recombinant human interleukin-1 receptor in HIV-1-infected patients.

Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research·1998
Same author

Management of AIDS-associated Kaposi's sarcoma: a multidisciplinary perspective.

Oncology (Williston Park, N.Y.)·1998
Same author

AIDS-related Kaposi's sarcoma: prospective validation of the AIDS Clinical Trials Group staging classification. AIDS Clinical Trials Group Oncology Committee.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology·1997
Same journal

Translational Analysis of Cytokine SNPs Reveals an Interplay Between Immune Response and Glucose Metabolism Following Mild-to-Moderate COVID-19.

Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research·2026
Same journal

IL-6-JAK2-STAT3 Signaling Pathway and the Pathogenesis of Chronic Tonsillitis.

Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research·2026
Same journal

A Stable Reporter Cell Line to Study Respiratory Syncytial Virus NS2-Mediated Inhibition of <i>IFNB</i> Promoter Activation.

Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research·2026
Same journal

Human Macrophages Secrete Both Interferon α and Interferon β Proteins During Infection with <i>Mycobacterium tuberculosis</i>.

Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research·2026
Same journal

Biochemical Signature in Deciphering the Metastasis-Associated Lung Adenocarcinoma Transcript 1/microRNA-145 Axis and Its Molecular Correlation with Nuclear Factor Kappa Beta/Transforming Growth Factor-Beta and Apoptotic Proteins Expression in Colorectal Cancer.

Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research·2026
Same journal

The Serum 25-Hydroxyvitamin D Response to Supplemental Vitamin D Is Temporarily Blunted with Elevated Circulating Cytokines at Baseline.

Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research·2026
See all related articles

Interferon-alpha (IFN-alpha) has evolved as a treatment for Kaposi

Area of Science:

  • Oncology
  • Immunology
  • Virology

Background:

  • Kaposi's sarcoma (KS) treatment in acquired immunodeficiency syndrome (AIDS) patients has evolved significantly over 15 years.
  • Early interferon-alpha (IFN-alpha) success predated human immunodeficiency virus (HIV) identification and a clear understanding of KS.

Purpose of the Study:

  • To review the advancements in IFN-alpha therapy for AIDS-associated KS.
  • To explore how improved understanding of AIDS, KS, and IFN-alpha biology impacts treatment.

Main Methods:

  • Review of scientific literature and clinical data spanning approximately 15 years.
  • Analysis of the interplay between HIV infection, KS pathogenesis, and IFN-alpha treatment efficacy.

Main Results:

Related Experiment Videos

  • IFN-alpha therapy for KS has become more rational and successful with increased biological and clinical knowledge.
  • Advances in HIV treatment and understanding of KS biology have enhanced IFN-alpha's role.

Conclusions:

  • Current IFN-alpha outcomes for KS can be further improved.
  • Future strategies should integrate advanced HIV therapies and anti-angiogenic cytokine inhibitors.