Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Clinical overview: issues in Kaposi's sarcoma therapeutics

S E Krown1

  • 1Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.

Journal of the National Cancer Institute. Monographs
|August 26, 1998
PubMed
Summary

Identifying Kaposi

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Management of Kaposi sarcoma: the role of interferon and thalidomide.

Current opinion in oncology·2001
Same author

Phase II, randomized, open-label, community-based trial to compare the safety and activity of combination therapy with recombinant interferon-alpha2b and zidovudine versus zidovudine alone in patients with asymptomatic to mildly symptomatic HIV infection. HIV Protocol C91-253 Study Team.

Journal of acquired immune deficiency syndromes and human retrovirology : official publication of the International Retrovirology Association·1999
Same author

Phase I/II trial of the type I soluble recombinant human interleukin-1 receptor in HIV-1-infected patients.

Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research·1998
Same author

Interferon-alpha: evolving therapy for AIDS-associated Kaposi's sarcoma.

Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research·1998
Same author

Management of AIDS-associated Kaposi's sarcoma: a multidisciplinary perspective.

Oncology (Williston Park, N.Y.)·1998
Same author

AIDS-related Kaposi's sarcoma: prospective validation of the AIDS Clinical Trials Group staging classification. AIDS Clinical Trials Group Oncology Committee.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology·1997

Area of Science:

  • Oncology
  • Virology
  • Immunology

Background:

  • Kaposi's sarcoma (KS) remains a significant challenge, particularly in immunocompromised individuals.
  • Current therapeutic and prophylactic strategies require refinement for improved patient outcomes.

Purpose of the Study:

  • To address critical questions for advancing Kaposi's sarcoma (KS) management.
  • To explore the translation of pathogenic insights into novel therapeutic and prophylactic approaches.
  • To examine the impact of human immunodeficiency virus (HIV) management on KS treatment strategies and evaluation.

Main Methods:

  • Review and synthesis of current knowledge on KS risk factors and pathogenesis.
  • Analysis of emerging therapeutic targets, including anti-angiogenesis and anti-cytokine strategies.
  • Consideration of the influence of effective antiretroviral therapy on KS treatment paradigms.

Main Results:

  • Accurate prediction of KS development requires further identification of high-risk factors.
  • Targeting KS pathogenesis, including viral factors and angiogenesis, shows promise for new therapies.
  • Improved HIV control necessitates adjustments in KS treatment timing, approach, and drug interaction monitoring.

Conclusions:

  • Developing predictive models for KS is crucial for prophylaxis trials.
  • Translating research on KS pathogenesis into targeted therapies is a key future direction.
  • Standardized, quantitative criteria for evaluating KS treatment benefits are essential for clinical practice and research.

Related Experiment Videos