Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

What questions can large, simple trials answer?

P Sandercock1

  • 1Department of Clinical Neurosciences, Western General Hospital, Edinburgh, UK.

Cerebrovascular Diseases (Basel, Switzerland)
|May 7, 1998
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Effectiveness of intermittent pneumatic compression in reduction of risk of deep vein thrombosis in patients who have had a stroke (CLOTS 3): a multicentre randomised controlled trial.

Lancet (London, England)·2013
Same author

CRASH-2 (Clinical Randomisation of an Antifibrinolytic in Significant Haemorrhage) intracranial bleeding study: the effect of tranexamic acid in traumatic brain injury--a nested randomised, placebo-controlled trial.

Health technology assessment (Winchester, England)·2012
Same author

Why the United States Center for Medicare and Medicaid Services (CMS) should not extend reimbursement indications for carotid artery angioplasty/stenting.

International angiology : a journal of the International Union of Angiology·2012
Same author

Why the United States Center for Medicare and Medicaid Services (CMS) should not extend reimbursement indications for carotid artery angioplasty/stenting.

European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery·2012
Same author

The timing, extent, progression and regression of deep vein thrombosis in immobile stroke patients: observational data from the CLOTS multicenter randomized trials.

Journal of thrombosis and haemostasis : JTH·2011
Same author

Current controversies: thrombolysis for patients with acute ischaemic stroke aged over 80.

The journal of the Royal College of Physicians of Edinburgh·2010
Same journal

JR-ZQSI-NICHE: A Digital Neurosurgical Decision Support System for Spontaneous Intracerebral Hemorrhage.

Cerebrovascular diseases (Basel, Switzerland)·2026
Same journal

Variations across Europe in national guidelines and clinical practice regarding screening of cognitive and emotional consequences after aneurysmal subarachnoid hemorrhage.

Cerebrovascular diseases (Basel, Switzerland)·2026
Same journal

Intravenous Thrombolysis Before Versus Direct Endovascular Treatment for Acute Ischemic Stroke Due to Large Vessel Occlusion: A Systematic Review and Meta-analysis.

Cerebrovascular diseases (Basel, Switzerland)·2026
Same journal

Erratum.

Cerebrovascular diseases (Basel, Switzerland)·2026
Same journal

Association between extubation timing and functional outcomes in patients with acute ischemic stroke after endovascular treatment.

Cerebrovascular diseases (Basel, Switzerland)·2026
Same journal

Achieving the 'golden hour': evaluating and optimising the spatial distribution of comprehensive stroke centers in Liaoning Province, China.

Cerebrovascular diseases (Basel, Switzerland)·2026
See all related articles

Large, simple clinical trials are essential for evaluating stroke treatments. These studies provide reliable evidence on treatment risks and benefits for millions of patients globally.

Area of Science:

  • Clinical Trials
  • Neurology
  • Public Health

Background:

  • Stroke affects millions globally, with millions of ischemic strokes occurring annually.
  • A significant number of stroke patients receive medical attention within hours of onset.
  • Reliable evidence is crucial for making informed treatment decisions for stroke patients.

Purpose of the Study:

  • To emphasize the necessity of large, simple randomized trials for stroke treatment evaluation.
  • To highlight the importance of evidence-based decision-making in stroke care.
  • To underscore the feasibility and affordability of large-scale trials.

Main Methods:

  • Focus on the design of large, simple randomized trials.
  • Emphasis on recruiting thousands of patients for robust statistical power.

Related Experiment Videos

  • Inclusion of diverse patient populations to ensure generalizability.

    • Main Results:

    • Large, simple trials yield reliable evidence on treatment risks and benefits.
    • Such trials are crucial for understanding treatment effects on mortality and other outcomes.
    • Evidence generated informs treatment decisions for a wide range of patients.

    Conclusions:

    • Large, simple randomized trials are the most effective method for evaluating widely applicable stroke treatments.
    • These trials provide essential data for optimizing patient care and treatment strategies.
    • The findings support the widespread adoption of simple trial designs in stroke research.