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Intestinal stricture in necrotizing enterocolitis

M J Bell, J L Ternberg, F B Askin

    Journal of Pediatric Surgery
    |June 1, 1976
    PubMed
    Summary
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    Infants surviving necrotizing enterocolitis (NEC) can develop intestinal strictures. These strictures, often found in the submucosa, may cause intestinal malfunction and require consideration in long-term infant care.

    Area of Science:

    • Pediatric Surgery
    • Neonatal Medicine
    • Gastroenterology

    Background:

    • Necrotizing enterocolitis (NEC) is a serious condition affecting premature infants.
    • Intestinal strictures are a known complication following NEC.
    • Understanding the incidence and characteristics of these strictures is crucial for patient outcomes.

    Purpose of the Study:

    • To investigate the incidence of intestinal strictures in infants who survived acute NEC.
    • To analyze the relationship between treatment methods and stricture development.
    • To evaluate the predictive value of initial radiographic findings for stricture formation.

    Main Methods:

    • Retrospective review of infants with NEC over a 3-year period.
    • Inclusion of previously reported cases of intestinal stricture post-NEC from literature.

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  • Histological examination of stricture tissue.

    • Main Results:

    • Eight of 43 NEC survivors developed intestinal strictures.
    • Four infants had multiple strictures after diversion procedures; four had single strictures after medical therapy.
    • Histology revealed wound healing, primarily in the submucosa; initial radiographs were not predictive.

    Conclusions:

    • Intestinal stricture is a significant complication in NEC survivors.
    • Stricture should be considered in the differential diagnosis of intestinal dysfunction in these infants.
    • Further research into prevention and management strategies is warranted.