Monitoring oxygen partial pressure in tissue using microdialysis sampling and membrane coated oxygen sensors

The use of microdialysis sampling coupled to oxygen sensors for monitoring oxygen tension in the tissue of animals was examined. The response time of the microdialysis sampling system was not different than oxygen sensors implanted directly in the tissue. The microdialysis system could be calibrated in vivo using the no-net-flux calibration method while directly implanted oxygen sensors had to rely on in vitro calibration. No difference was found in the oxygen tensions determined in vivo between microdialysis sampling and direct sensor implantations.