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Pulmonary blood flow distribution during partial liquid ventilation

A Doctor1, J C Ibla, B M Grenier

  • 1Critical Care Research Laboratory, Department of Anesthesia, Children's Hospital, Boston, Massachusetts 02115, USA.

Journal of Applied Physiology (Bethesda, Md. : 1985)
|June 6, 1998
PubMed
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Partial liquid ventilation (PLV) alters regional pulmonary blood flow in lambs, reversing established patterns seen with conventional mechanical ventilation (CMV). This study highlights significant shifts in lung perfusion during PLV.

Area of Science:

  • Pulmonary Physiology
  • Respiratory Medicine
  • Medical Imaging

Background:

  • Conventional mechanical ventilation (CMV) in supine subjects typically results in pulmonary blood flow favoring dependent lung regions.
  • Understanding regional blood flow is crucial for optimizing mechanical ventilation strategies, especially in critical care settings.

Purpose of the Study:

  • To investigate the effects of partial liquid ventilation (PLV) on regional pulmonary blood flow distribution in supine lambs.
  • To compare blood flow patterns during PLV with those during CMV and assess the impact of incremental perfluorocarbon liquid dosing.

Main Methods:

  • Radiolabeled microspheres were used to quantify regional pulmonary blood flow in four supine lambs.
  • Lungs were analyzed post-mortem by sectioning and scintillation counting to determine flow distribution.

Related Experiment Videos

  • Lambs underwent transitions from CMV to PLV with incremental perfluorocarbon doses (up to 30 ml/kg), with CMV-supported lambs serving as controls.

    • Main Results:

    • During CMV, blood flow favored dependent lung regions without significant apical-to-diaphragmatic gradients.
    • PLV reversed transverse plane gradients, favoring nondependent lung regions, particularly in the hilar area.
    • PLV led to reduced flow near the diaphragm and established a dose-augmented apical flow gradient.

    Conclusions:

    • Regional pulmonary blood flow patterns during PLV are partially reversed compared to CMV.
    • PLV induces significant, dose-dependent alterations in lung perfusion, varying dramatically from apex to diaphragm.