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Related Experiment Videos

Continuous renal replacement therapy: evolution in technology and current nomenclature

C Ronco1, R Bellomo

  • 1Department of Nephrology, St. Bortolo Hospital, Vicenza, Italy.

Kidney International. Supplement
|May 9, 1998
PubMed
Summary

Advancements in renal replacement therapies, including continuous venovenous hemofiltration (CVVH) and hemodiafiltration (HDF), improve efficiency and solute clearance for critically ill patients. Newer continuous renal replacement therapy (CRRT) systems enhance safety and efficacy in managing acute kidney injury.

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Area of Science:

  • Nephrology
  • Critical Care Medicine
  • Biomaterials Engineering

Background:

  • Technological and biomaterial advancements drive progress in renal replacement therapies for acute, critically ill patients.
  • Continuous arteriovenous hemofiltration (CAVH) has evolved into newer techniques like continuous venovenous hemofiltration (CVVH), hemodiafiltration (HDF), and high flux dialysis (HFD).

Purpose of the Study:

  • To review the evolution and clinical utilization of various continuous renal replacement therapy (CRRT) techniques.
  • To highlight improvements in efficiency and solute clearance offered by advanced CRRT modalities.
  • To discuss the role of modern CRRT systems in managing critically ill patients with acute kidney injury and sepsis.

Main Methods:

  • Review of existing literature on continuous renal replacement therapy (CRRT) techniques.

Related Experiment Videos

  • Analysis of technological developments in dialyzers and CRRT system hardware/software.
  • Examination of clinical outcomes related to urea and larger solute clearance.

    • Main Results:

    • Modern CRRT techniques achieve high daily urea clearances exceeding 50 liters.
    • Highly permeable dialyzers enhance the removal of larger solutes, including inflammatory mediators.
    • Recent observations suggest the efficacy of high-volume fluid exchange in hemofiltration.

    Conclusions:

    • Continuous renal replacement therapy (CRRT) has significantly advanced, offering improved efficiency and broader solute removal capabilities.
    • Advanced hardware and software in newer CRRT systems are crucial for safe and effective treatment of critically ill patients.
    • These therapies play a vital role in managing acute inflammation and sepsis in critically ill patients.