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Related Experiment Videos

Positive and negative acute phase proteins in affective subtypes

M Hornig1, D B Goodman, M Kamoun

  • 1Laboratory for Neurovirology, University of California-Irvine, 92697-4292, USA.

Journal of Affective Disorders
|May 9, 1998
PubMed
Summary

Lithium treatment may normalize elevated C-reactive protein (CRP) levels in patients with affective disorders, suggesting a role for lithium in managing systemic immune activation associated with depression. Further research is needed to confirm these findings in specific patient subgroups.

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Area of Science:

  • Neuroscience
  • Psychiatry
  • Immunology

Background:

  • Patients with affective disorders exhibit altered levels of acute phase proteins, including elevated C-reactive protein (CRP) and decreased transferrin (TFN).
  • Previous studies suggest CRP reductions correlate with lithium augmentation response in depression.
  • The relationship between systemic immune markers and affective disorder subtypes, mood, and medication remains underexplored.

Purpose of the Study:

  • To investigate the association between affective disorder subtypes and levels of CRP and TFN.
  • To explore the influence of psychotropic medications, particularly lithium, on these immune markers.
  • To examine how mood state, age, and gender impact systemic immune markers in affective disorders.

Main Methods:

  • Assessed CRP and TFN levels in outpatients with bipolar I (n=79), bipolar II (n=24), and unipolar depression (n=46).

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  • Included a comparison group of 22 healthy controls.
  • Analyzed data considering diagnosis, medication, mood state, age, and gender.

    • Main Results:

    • Lithium monotherapy was associated with significantly lower CRP levels.
    • A similar trend of reduced CRP was observed in patients taking lithium with antidepressants.
    • CRP levels did not significantly differ across psychotropic medications, affective subgroups, or mood states.
    • TFN levels were not influenced by diagnosis, mood state, or psychotropic medications.

    Conclusions:

    • Lithium may play a role in normalizing immune activation in depression.
    • The findings suggest lithium's potential impact on systemic inflammation in affective disorders.
    • Further research is warranted to determine if these immune changes are specific to lithium-responsive subgroups.