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Updated: Aug 11, 2026

A Capsule-Based Model for Immature Hard Tick Stages Infestation on Laboratory Mice
Published on: July 9, 2020
[Iodoantipyrine--an agent for treating and preventing tick-borne encephalitis]
V E Iavorovskaia1, A S Saratikov, Iu V Fedorov
1Siberian Medical University, Tomsk, Russia.
Abstract:
The antiviral activity of iodantipyrine was studied in outbred [correction of inbred] albino mice (weight 10-12 g) infected with the Absettarov strain of the tick-borne encephalitis virus. Iodantipyrine was administered per os or parenterally and the animals were observed for 21 days. A reliable therapeutic effect was produced in 60% of mice infected with 10 DL50 of tick-borne encephalitis virus which were given the drug per os in a dose of 50 mg/kg. Preventive administration of the drug was effective in 47% of the animals.
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