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Related Experiment Videos

[Hepatocytes in cell therapy]

B Clément1, M Desille, B Frémond

  • 1Unité détoxication et réparation tissulaire, Inserm U456, Université Rennes I, France.

Transfusion Clinique Et Biologique : Journal De La Societe Francaise De Transfusion Sanguine
|May 13, 1998
PubMed
Summary
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This study developed a novel bioartificial liver using alginate-entrapped porcine hepatocytes. This cell-based therapy shows promise for treating liver failure and genetic defects, offering an alternative to transplantation.

Area of Science:

  • Hepatology
  • Biotechnology
  • Regenerative Medicine

Context:

  • Acute liver failure necessitates alternative treatments to orthotopic liver transplantation.
  • Cell-based therapies offer potential for restoring liver function and correcting genetic defects.
  • Existing bioartificial liver devices face challenges with flat substrates, hollow fibers, and microcarriers.

Purpose:

  • To develop a reliable extracorporeal bioartificial liver using alginate-entrapped hepatocytes.
  • To assess the efficacy of this system in correcting genetic defects, exemplified by the Gunn rat model.
  • To evaluate the suitability of porcine hepatocytes for large-scale, clinical applications.

Summary:

  • Porcine hepatocytes were isolated and immobilized within alginate beads for an extracorporeal bioartificial liver system.

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  • The system successfully corrected the Gunn rat's genetic defect in bilirubin conjugation.
  • Porcine hepatocytes demonstrated high liver functions, including detoxification and biotransformation, and offered immunoisolation and cryopreservation capabilities.

    • Impact:

    • This alginate-entrapped hepatocyte system presents a promising tool for developing extracorporeal bioartificial livers for human clinical use.
    • It offers a potential alternative or bridge therapy for patients with acute liver failure.
    • The system could enable the treatment of genetic liver diseases through cell-based therapy.