[Effect of the enterosorbent Aqualen on intestinal carcinogenesis induced by 1,2-dimethylhydrazine in rats]

Subcutaneous injections of 21 mg/kg 1,2-dimethylhydrazine were given weekly to 134 female LI0 rats. In the first series, 73 rats received 15 injections while 63 animals--5 injections (series 11). Some rats were also fed Aqualen (0.1 or 1.0 g/kg b.w.) during the whole experiment (6 months). In run 1, all animals developed malignant tumors of the colon. However, multiple tumors in Aqualen-fed rats were significantly less frequent than in those receiving carcinogenic agent alone. Also, Aqualen appeared to inhibit the development of carcinoma in the small intestine. In run 11, Aqualen treatment was followed by decreased incidence and multiplicity of tumors both in the entire large intestine and ascending and descending colon. Rectal tumor incidence was lower, too. In both runs, tumor size in enterosorbent-fed animals was smaller than in controls. All intestinal tumors were adenocarcinomas. No pathology was observed in Aqualen-fed rats untreated with the carcinogenic agent.