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Pediatric sertraline overdose

G Catalano1, D S Cooper, M C Catalano

  • 1Department of Psychiatry, University of South Florida College of Medicine, Tampa, USA.

Clinical Neuropharmacology
|May 14, 1998
PubMed
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Sertraline (Zoloft) is a selective serotonin reuptake inhibitor used for mood and anxiety disorders. This review examines pediatric sertraline overdose cases, including a specific infant ingestion, and discusses treatment strategies.

Area of Science:

  • Pharmacology
  • Pediatric Medicine
  • Toxicology

Background:

  • Sertraline, a selective serotonin reuptake inhibitor (SSRI), is widely prescribed for mood and anxiety disorders in adults.
  • While used off-label in pediatric populations, sertraline lacks formal FDA approval for children.
  • Its favorable side effect profile and improved safety in overdose compared to tricyclic antidepressants contribute to its increasing use.

Observation:

  • Reports of sertraline overdose in adults are frequent, but pediatric cases are less common.
  • This review synthesizes existing literature on pediatric sertraline overdose.
  • A specific case of sertraline ingestion in a 22-month-old infant is presented.

Findings:

  • The review details the characteristics and outcomes of pediatric sertraline overdose.

Related Experiment Videos

  • The presented infant case illustrates a real-world scenario of overdose in a young child.
  • Analysis of the case and literature provides insights into managing pediatric sertraline toxicity.

    • Implications:

    • Understanding pediatric sertraline overdose is crucial for clinicians managing pediatric mental health.
    • This information aids in developing appropriate treatment protocols for accidental or intentional ingestion in children.
    • Further research may inform FDA approval and guideline development for pediatric sertraline use.