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Antiviral effect of trimeric 2',5'-oligoadenylic acid and some of its analogues
Tkachuk ZYu1, L I Semernikova, V V Tkachuk
1Institute of Molecular Biology and Genetics, National Academy of Sciences of Ukraine, Kiev.
The New Microbiologica
|May 14, 1998
Abstract:
The antiviral effect of 2',5'-trioligoadenylate (2',5'-A3) and some of its analogues was studied using several model cell culture systems and viruses: mice L929 fibroblast cells inoculated with vaccine virus, testicular piglet cells inoculated with Aueszki disease virus (strain BUK-628), and the same culture inoculated with a reference strain of transmissible gastroenteritis virus, strain Purdue-115. Our results suggest that both 2',5'-trioligoadenylate and its analogues are promising antiviral substances against DNA- and RNA-containing viruses.