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Alteration of carotid circulation in essential hypertensive patients with left ventricular hypertrophy

Y N Jiang1, K Kohara, K Hiwada

  • 1The Second Department of Internal Medicine, Ehime University School of Medicine, Japan.

Journal of Human Hypertension
|May 14, 1998
PubMed

Insights

Essential hypertension patients with left ventricular hypertrophy show impaired diastolic blood flow in the common carotid artery. This is linked to reduced arterial distensibility and lower diastolic perfusion pressure.

Area of Science:

  • Cardiovascular Medicine
  • Medical Ultrasound
  • Hypertension Research

Background:

  • Essential hypertension is a significant risk factor for cardiovascular disease.
  • Left ventricular hypertrophy (LVH) is a common complication of essential hypertension.
  • Carotid artery haemodynamics may reflect systemic vascular changes in hypertensive patients.

Purpose of the Study:

  • To assess carotid artery haemodynamic characteristics in essential hypertensive patients with and without left ventricular hypertrophy (LVH).
  • To investigate the relationship between carotid artery structure, function, and blood flow in these patient groups.

Main Methods:

  • Utilized B-mode ultrasound and pulsed-Doppler to evaluate common carotid artery structure, function, and blood flow.
  • Compared measurements between control subjects (n=38), hypertensive patients without LVH (n=27), and hypertensive patients with LVH (n=40).

Main Results:

  • Hypertensive patients exhibited increased intima-medial thickness compared to controls.
  • Hypertensive patients with LVH showed significantly decreased diastolic/systolic flow velocity and flow volume ratios.
  • These decreases were associated with reduced common carotid artery distensibility.
  • Diastolic/systolic flow velocity and flow volume ratios correlated with blood pressure and carotid distensibility in hypertensive patients with LVH.

Conclusions:

  • Diastolic blood flow in the common carotid artery is impaired in essential hypertensive patients with LVH.
  • Reduced carotid arterial distensibility and low diastolic perfusion pressure are potential underlying mechanisms for impaired diastolic flow.

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