Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Prions and the problems they raise]

A Burny1

  • 1Faculté universitaire des Sciences agronomiques de Gembloux.

Bulletin Et Memoires De L'Academie Royale De Medecine De Belgique
|January 1, 1997
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Cellular dynamics of pathogenesis induced by bovine leukemia virus].

Virologie (Montrouge, France)·2022
Same author

[From fundamental research to translational research in oncology].

Revue medicale de Liege·2021
Same author

Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality.

Leukemia·2017
Same author

Evolution of microRNA expression during human bronchial squamous carcinogenesis.

The European respiratory journal·2008
Same author

The role of NPM, p14arf and MDM2 in precursors of bronchial squamous cell carcinoma.

The European respiratory journal·2008
Same author

HTLV-I infection of WE17/10 CD4+ cell line leads to progressive alteration of Ca2+ influx that eventually results in loss of CD7 expression and activation of an antiapoptotic pathway involving AKT and BAD which paves the way for malignant transformation.

Leukemia·2007

Prions are infectious proteins implicated in neurodegenerative diseases like spongiform encephalopathies. Research is urgently needed to understand their role and the prion theory

Area of Science:

  • Neurobiology
  • Protein Chemistry
  • Genetics

Background:

  • Prions are infectious proteins linked to neurodegenerative diseases.
  • The prion concept extends to dominant cytoplasmic heredity in yeast.
  • Amyloid fibrils, aggregated prions, may appear late in disease progression.

Purpose of the Study:

  • To summarize current understanding of prions and their role in disease.
  • To highlight uncertainties regarding the prion's composition and function.
  • To emphasize the need for further prion research.

Main Methods:

  • Literature review of recent publications on prions.
  • Discussion of experimental neuropathies and yeast heredity.
  • Analysis of the implications of prion theory for protein folding.

Related Experiment Videos

Main Results:

  • Prions are strongly associated with spongiform encephalopathies.
  • Amyloid fibrils might not be the earliest indicator of prion disease.
  • The exact composition of the infectious agent remains uncertain.

Conclusions:

  • Prion research is critical for understanding neurodegenerative diseases.
  • The prion theory presents significant challenges to protein folding chemistry.
  • Further contributions to prion research are urgently required.