[Pathology of traumatic disease in wounded people]

The hemodynamic concept of TD pathogenesis and morphogenesis is based on the vascular response initiated by neuroendocrine mechanisms. Their effect in grave wounds is potentiated by blood loss, shock, endotoxicosis as well as inadequate therapy. Secondary damage to organs with clinical syndrome of their failure results from impaired correlation between the plasticity of histones and speed of microcirculatory alterations. Periodization of TD is suggested that takes into account its cyclicity and specificity of time distribution of therapeutic and diagnostic actions. Cerebral, pulmonary, renal, cardiac, gastro-intestinal and mixed forms of TD are distinguished.