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Related Experiment Videos

Indinavir-associated lipodystrophy

R Viraben1, C Aquilina

  • 1Service de Dermatologie, Toulouse, France.

AIDS (London, England)
|May 16, 1998
PubMed
Summary
This summary is machine-generated.

Protease inhibitor therapy can cause lipodystrophy, a rare condition of subcutaneous fat loss. This disfigurement may be an unwanted side effect, potentially linked to metabolic changes.

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Area of Science:

  • Dermatology
  • Endocrinology
  • Pharmacology

Background:

  • Lipodystrophies are rare genetic disorders causing symmetrical loss of subcutaneous fat.
  • Associated conditions include diabetes mellitus and insulin resistance.

Observation:

  • Eight patients developed partial or generalized lipodystrophy after protease inhibitor therapy (indinavir).
  • Onset occurred within 2-12 months, unrelated to weight loss or skin disease.

Findings:

  • Lipodystrophy persisted after therapy withdrawal.
  • One patient developed glycosuria; glucose tolerance tests revealed hyperinsulinemia.

Implications:

  • Lipodystrophy appears to be an adverse effect of protease inhibitors.
  • This condition can cause significant cosmetic disfigurement and metabolic disturbances.