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The risk for recurrence of premature births to African-American and white women
1Department of Pediatrics, University of Chicago Pritzker School of Medicine, Illinois, USA.
Insights
African American women have higher preterm birth rates than white women. Recurrence of preterm birth is common, especially for African American women after their first or second pregnancy.
Area of Science:
- Obstetrics and Gynecology
- Perinatal Health
- Health Disparities
Background:
- Preterm birth is a significant concern in maternal and infant health.
- Existing data suggest racial disparities in preterm birth rates, with African Americans experiencing higher rates than whites.
- The recurrence risk of preterm birth, particularly across different pregnancies and racial groups, requires further investigation.
Purpose of the Study:
- To test the hypothesis that both initial and recurrent preterm birth rates are higher for African Americans compared to whites.
- To define the recurrence risk of preterm birth in relation to previous pregnancy outcomes.
- To identify specific populations at higher risk for recurrent preterm birth.
Main Methods:
- A cohort study was conducted involving African-American and white women delivering singleton infants between 1988 and 1993.
- Inclusion criteria included known reproductive history, delivery of at least two singletons, and no planned abortions, miscarriages, or induced preterm labor.
- Preterm birth was defined as delivery at less than 37 completed weeks of gestation.
Main Results:
- The overall preterm birth rate was significantly higher for African Americans (24.5%) than for whites (11.1%).
- Among African Americans, the preterm birth rate for the second pregnancy (30.6%) was significantly higher than for the first (18.2%).
- Recurrence accounted for a substantial proportion of preterm births, with higher rates observed in African American women after the second pregnancy (68% vs. 41.7% in white women).
Conclusions:
- Preterm births are common for both African Americans and whites within the first two pregnancies.
- African-American women with a history of preterm birth in their first or second pregnancy need targeted management strategies to prevent recurrence.
- Addressing racial disparities in preterm birth and understanding recurrence patterns are crucial for improving perinatal outcomes.
Abstract:
Preterm birth rates are higher for African Americans than for whites, but the risk for recurrence is not well defined. We tested the hypothesis that the base and recurrence rates for premature births are higher for African Americans than for whites. We recruited a cohort of African-American and white women giving birth to singleton infants between 1988 and 1993 at Perinatal Network, a Midwest urban teaching hospital. These women had known reproductive history, delivered two or more singletons, and had no planned abortions, miscarriages, or induced preterm labor. Premature infants were born at less than 37 completed weeks of gestation. The total preterm birth rate among African Americans was 24.5%, significantly higher than the 11.1% for whites (relative risk, 2.22; confidence interval, 1.79 to 2.75). The preterm birth rate among African Americans for the second pregnancy was 30.6%, significantly higher than the rate of 18.2% for the first pregnancy and 24.5% for the third and fourth pregnancies. The preterm birth rates for whites were 11.7% for the first pregnancy, 9.8% for the second, and 12.9% for the third and fourth pregnancies, which were not significantly different from each other. Considering only the first two pregnancies, recurrence accounted for 32.6% of all premature births for both African Americans and whites. After the second pregnancy, 68% of African-American and 41.7% of white premature babies were born to women who had previous preterm infants. We conclude that preterm births are relatively common for African Americans and whites in the first two pregnancies. Women, particularly African-American women with a previous preterm birth at either the first or second pregnancy, require more specific management to prevent recurrence of preterm birth.
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