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A highly efficient synthesis of cyclaradine and its behaviour towards adenosine deaminase
N Katagiri1, H Kokufuda, M Makino
1Pharmaceutical Institute, Tohoku University, Sendai, Japan.
Nucleic Acids Symposium Series
|January 1, 1997
Abstract:
(+)-, (-)-, and (+/-)-Cyclaradines were efficiently synthesized from 2-aza-bicyclo[2.2.1]hept-5-en-3-one (ABH). (+)- and (+/-)-Cyclaradines were deaminated by adenosine deaminase whereas (-)-cyclaradine was not hydrolyzed under the same conditions.