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Specific interaction between 5'-aminonucleosides and borates and influence of borates on nucleoside conformations
T Wada1, N Minamimoto, Y Inaki
1Faculty of Engineering, Osaka University, Japan.
Nucleic Acids Symposium Series
|January 1, 1997
Abstract:
The unique conformation and orientational change of 5'-amino-5'-deoxyuridine in Kolthoff's buffer is discussed. From CD and NOE spectra, anomalous syn orientation of Urd-5'-NH2 might be caused by specific interaction between borates and Urd-5'-NH2, which promote the formation of hydrogen bonding between 2-carbonyl oxygen and hydrogen of 5'-amino group. This borates induced syn orientation of Urd-5'-NH2 could be applied to external stimulation control of target RNA/DNA hybridization.