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Synthesis of the 2'-deoxy-2'-fluoro and 3'-deoxy-3'-fluoro analogues of 8-bromoadenosine
T Maruyama1, Y Sato, T Sakamoto
1Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Japan.
Nucleic Acids Symposium Series
|January 1, 1997
Abstract:
After protection of the two sugar hydroxyl groups of 8-bromoadenosine, the products were converted to the arabinoside or xyloside, which were treated with diethy laminosulfur trifluoride (DAST) and acid to afford 2'-deoxy-2'-fluoro- or 3'-deoxy-3'-fluoro-8-bromoadenosine. 8-OH and 8-SH derivatives were obtained from 8-bromo congener.