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[Neurobiology of erectile dysfunction in multiple sclerosis]
J Salinas Casado1, M Vírseda Chamorro, R Samblás García
1Servicio de Urología, Hospital Universitario San Carlos, Universidad Complutense, Madrid, España.
Objective:
To analyze the neurological alterations responsible for impotence in multiple sclerosis.
Methods:
We conducted a pharmacologic erection test and a neuroandrologic profile study in 11 patients with multiple sclerosis and impotence. This study consisted in: bulbocavernosus EMG, S2-S4 evoked potentials, somatosensory potentials of pudendal nerve, electromyography of cavernous smooth muscle (SPACE), sympathetic skin response (SSR) and cystometry.
Results:
The most frequent neurological lesion was complete suprasacral (7 cases; 64%) and parasympathetic (7 cases; 64%) lesions. The parasympathetic lesions were of the upper motor neuron type in 6 of the 7 cases (86%). Peripheral autonomic [sympathetic in 2 cases (18%); parasympathetic in 1 case (9%)] and pudendal lesions (3 cases; 27%) were also observed.
Conclusions:
The main cause of impotence in multiple sclerosis could be ascribed to a suprasacral lesion. Some cases also present peripheral autonomic lesions.