[Hypertonic-hyperoncotic volume replacement with Tensitone]

Area of Science:

• Emergency Medicine
• Critical Care Medicine
• Pharmacology

Background:

• Hypertonic-hyperoncotic solutions (HHS) represent an advanced approach to volume restoration in hypovolemia.
• Tensitone (7.5% NaCl in 6% dextran 70) is a specific HHS formulation evaluated for clinical use.

Purpose of the Study:

• To assess the efficacy and safety of Tensitone for volume restoration in patients experiencing massive acute blood loss.
• To compare the effects of Tensitone with standard volume expanders in managing hemorrhage.

Main Methods:

• A multicenter clinical study involving 81 patients with massive traumatic or peroperative hemorrhage.
• Rapid infusion of a small volume of Tensitone (4 ml/kg) was administered and compared to standard volume expanders (N=34).
• Evaluation focused on hemodynamic parameters, diuresis, and overall patient condition.

Main Results:

• Tensitone demonstrated a significantly faster and more pronounced normalization of blood pressure (p < 0.01) and heart rate (p < 0.05) compared to standard expanders.
• Rapid hemodynamic improvement was observed within 10 minutes, with sustained effects for at least 2 hours.
• Central venous pressure and diuresis also showed significant improvement (p < 0.01) with Tensitone.
• The preparation exhibited good tolerance, with serious adverse effects like thrombophlebitis occurring in only 3.6% of patients.

Conclusions:

• Tensitone is an effective and safe option for rapid, small-volume resuscitation in cases of massive blood loss.
• Its application aligns with contemporary practices in intensive care and acute medicine.
• The study supports the use of Tensitone for prompt hemodynamic stabilization during critical bleeding events.