Related Experiment Video
Updated: Oct 1, 2026

MRI and PET in Mouse Models of Myocardial Infarction
Published on: December 19, 2013
Contrast enhanced and functional magnetic resonance imaging for the detection of viable myocardium after infarction
P Dendale1, P R Franken, P Block
1Department of Cardiology, Free University of Brussels (VUB), Belgium.
Purpose:
Viable myocardium after acute myocardial infarction may be characterized by magnetic resonance imaging (MRI) either by demonstration of recovery of wall motion under dobutamine stress or by perfusion patterns after contrast medium administration. This study examines the relation between the two techniques.
Materials And Methods:
Gradient-echo MRI at rest and under low-dose dobutamine stress was performed in 28 patients within the first 2 weeks after acute myocardial infarction. In addition, spin-echo MRI was performed after gadolinium-DOTA administration. Wall motion at rest and under stress was scored to assess the contractile reserve of the infarct regions. Infarct enhancement patterns were classified as subendocardial, transmural, or as a doughnut pattern.
Result:
Subendocardial or absent infarct enhancement was related to functional recovery under stress in 31 of 37 infarct segments. Transmural infarct enhancement was correlated with the absence of functional recovery in 10 of 17 infarct segments (p < 0.002), indicating nonviability. The doughnut pattern was exclusively associated with the absence of viability (five of five).
Conclusion:
Contrast enhancement patterns are related to residual myocardial viability.
Related Concept Videos
Magnetic Resonance Imaging
Imaging Studies for Cardiovascular System II:Types of Echocardiography
Types of Echocardiography
Transthoracic Echocardiography (TTE)
TTE is the most common type of echocardiogram which involves placing a transducer on the patient's chest, emitting sound waves to create heart images. TTE is invaluable for evaluating the heart's size, structure, and motion, making it particularly useful for diagnosing...
Imaging Studies for Cardiovascular System IV: CMRI
Imaging Studies for Cardiovascular System V: CT
Acute Coronary Syndrome III: Diagnostic Studies

