Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Hyperhomocyst(e)inemia and endothelial dysfunction in IDDM

M A Hofmann1, B Kohl, M S Zumbach

  • 1Department of Medicine, University of Heidelberg, Germany.

Diabetes Care
|May 20, 1998
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Response to Letter to the Editor re: "Treatment outcomes of functional urinary incontinence in children after structured urotherapeutic training".

Journal of pediatric urology·2025
Same author

Treatment outcomes of functional urinary incontinence in children after structured urotherapeutic training.

Journal of pediatric urology·2025
Same author

Correction to: The receptor for advanced glycation end products (RAGE) sustains autophagy and limits apoptosis, promoting pancreatic tumor cell survival.

Cell death and differentiation·2025
Same author

Negative cooperativity regulates ligand activation of DIAPH1 and other diaphanous related formins.

Communications biology·2025
Same author

Water-Based Polyurethane Dispersions: A Detailed Analysis of the Particle Charge Using Soft and Hard Particle Model.

Langmuir : the ACS journal of surfaces and colloids·2024
Same author

Two separate, large cohorts reveal potential modifiers of age-associated variation in visual reaction time performance.

NPJ aging and mechanisms of disease·2021
Same journal

A Secular Increase in the Incidence of Islet Autoimmunity Among Colorado Children With Moderate-Risk HLA Genotypes.

Diabetes care·2026
Same journal

Clinical and Biochemical Recovery From Immune Checkpoint Inhibitor-Induced Diabetes With Seroconversion of GAD Antibodies.

Diabetes care·2026
Same journal

State Insulin Out-of-Pocket Cap Policies and Estimated Eligible Populations in the United States, 2019-2026.

Diabetes care·2026
Same journal

Genetic Determinants of Macronutrient Intake Are Associated With Specific Food Intake in Youth: A Cohort Study Across Childhood and Adolescence.

Diabetes care·2026
Same journal

A Novel Electronic Medical Record Search Method to Identify Patients With Ketosis-Prone Diabetes: Implications for Discovery of Atypical Diabetes.

Diabetes care·2026
Same journal

Real-Time Continuous Glucose Monitoring Among People With Type 2 Diabetes and End-Stage Kidney Failure Undergoing Maintenance Hemodialysis: A Randomized Clinical Trial.

Diabetes care·2026
See all related articles

Elevated homocysteine levels are common in type 1 diabetes patients and linked to microvascular complications like nephropathy and retinopathy. This suggests homocysteine contributes to the increased cardiovascular risk seen in these patients.

Area of Science:

  • Endocrinology
  • Cardiovascular Medicine
  • Metabolic Disorders

Background:

  • Elevated homocysteine is an independent risk factor for macrovascular disease.
  • Diabetic microvascular complications contribute significantly to morbidity and mortality.
  • Understanding the link between homocysteine and diabetic complications is crucial for risk stratification.

Purpose of the Study:

  • To investigate the association between hyperhomocysteinemia and microvascular complications in patients with type 1 diabetes.
  • To determine if elevated homocysteine levels correlate with markers of endothelial damage and diabetic complications.

Main Methods:

  • Measured plasma homocysteine and thrombomodulin levels in 75 type 1 diabetes patients and 40 controls before and after methionine loading.

Related Experiment Videos

  • Assessed albumin excretion rates and prevalence of diabetic complications (nephropathy, retinopathy, neuropathy, macroangiopathy).
  • Conducted in vitro experiments using human umbilical vein cells to explore the interaction of homocysteine and advanced glycation end products (AGEs).

    • Main Results:

    • Type 1 diabetes patients exhibited significantly higher homocysteine levels compared to controls.
    • A subset of patients (26/75) presented with hyperhomocysteinemia.
    • Hyperhomocysteinemia was associated with elevated thrombomodulin, increased albumin excretion, and a higher prevalence of nephropathy, retinopathy, neuropathy, and macroangiopathy.

    Conclusions:

    • Hyperhomocysteinemia is prevalent in diabetic patients, particularly those with nephropathy.
    • Homocysteine may play a synergistic role with AGEs in promoting vascular damage in diabetes.
    • Managing homocysteine levels could be a potential strategy to reduce cardiovascular risk in type 1 diabetes.