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[A study of 5-fluorouracil on bovine trabecular meshwork cells in vitro]
1Department of Ophthalmology, Union Hospital, Tongji Medical University, Wuhan.
[Zhonghua Yan Ke Za Zhi] Chinese Journal of Ophthalmology
|November 1, 1996
Abstract
Objective:
To determine whether the clinical use of 5-fluorouracil (5-FU) may have any toxic effects on trabecular meshwork cells.
Methods:
Bovine trabecular meshwork (BTM) cells were cultured in vitro. The effects of 5-FU on BTM cells concerning cellular morphology, ultrastructure, vitality and phagocytosis were observed.
Result:
The safe dosage of 5-FU on BTM cell was 1 x 10-6g.ml-1.
Conclusion:
Based on the pharmacokinetic data in the rabbit anterior chamber, it is suggested that the 5-FU dosage of conventional use cause no injury to human trabecular meshwork cells.