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Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?
Published on: June 13, 2014
Maleic acid is an aldose reductase inhibitor
1Biorex Research and Development Co., Veszprém, Hungary.
Abstract:
The effects of a series of dicarboxylic acids on aldose reductase activity were investigated in a crude enzyme preparation obtained from ocular lenses of the swine. Of the compounds examined, maleic acid inhibited aldose reductase in a pronounced manner and in a concentration-dependent fashion (IC50 value of 83.0 +/- 1.4 mM). Saturation experiments revealed non-competitive kinetics with a Ki value of 64.9 +/- 1.7 mM. The present results suggest that, at higher doses, maleic acid might have some implication for the treatment of diabetic complications.
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