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Related Experiment Videos

Bcr/Abl associated leukemogenesis in bcr null mutant mice

J W Voncken1, V Kaartinen, J Groffen

  • 1Department of Pathology, Childrens Hospital of Los Angeles Research Institute, California 90027, USA.

Oncogene
|May 20, 1998
PubMed
Summary

The Bcr protein does not significantly contribute to Philadelphia-positive leukemia development. Researchers found that the P190 BCR/ABL oncogene causes leukemia even in mice lacking the Bcr protein.

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Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • The BCR gene plays a role in Philadelphia-chromosome-positive leukemogenesis.
  • One proposed mechanism involves the interaction of the normal Bcr protein with the Bcr/Abl oncoprotein.

Purpose of the Study:

  • To investigate the in vivo role of the Bcr protein in leukemia development.
  • To test the hypothesis that Bcr protein interaction is essential for Bcr/Abl-mediated leukemogenesis.

Main Methods:

  • Introduction of a P190 BCR/ABL transgene into mice lacking endogenous Bcr protein.
  • Comparison of leukemia latency and clinical patterns in Bcr-deficient mice versus control mice.

Main Results:

  • The P190 BCR/ABL oncogene induced leukemia in Bcr-deficient mice.

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  • Leukemia development showed indistinguishable latency and clinical patterns compared to genetically matched controls.

    • Conclusions:

    • The Bcr protein does not play a significant or major role in the development of leukemia mediated by the P190 BCR/ABL oncogene.
    • The Bcr/Abl oncoprotein can induce leukemia independently of the normal Bcr protein's function.