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[Spherical crystallization in pharmaceutical technology]

R P Szabóné1, H K Pintyéné, P Kása

  • 1Szent-Györgyi Albert Orvostudományi Egyetem, Gyógyszertechnológiai Intézet, Szeged.

Acta Pharmaceutica Hungarica
|May 21, 1998
PubMed
Summary
This summary is machine-generated.

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Spherical crystals improve pharmaceutical applications due to enhanced flow and compressibility, aiding direct tablet making and capsule filling. Controlling crystallization processes is key to achieving desired crystal properties for drug formulation.

Area of Science:

  • Materials Science
  • Pharmaceutical Sciences
  • Chemical Engineering

Context:

  • Crystalline material properties like size, distribution, and morphology are crucial for pharmaceutical applications.
  • Spherical crystals offer advantages in direct tablet manufacturing and capsule filling due to superior flowability and compressibility.
  • The crystallization process significantly influences these physical properties.

Purpose:

  • To review and present findings on spherical crystals for pharmaceutical applications.
  • To highlight the benefits of spherical crystal morphology in drug formulation.
  • To consolidate literature and experimental data on spherical crystals.

Summary:

  • This work compiles literature and experimental data on spherical crystals, including single crystals, poly-crystals, and agglomerates with excipients.

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  • It emphasizes how controlling crystallization processes can yield spherical crystals with desirable pharmaceutical properties.
  • The study details the advantages of spherical crystals for direct tablet making and capsule filling.

    • Impact:

    • Facilitates the development of improved pharmaceutical formulations with enhanced drug delivery characteristics.
    • Highlights the importance of interdisciplinary collaboration between chemists and pharmaceutical technologists.
    • Provides a foundation for optimizing crystallization techniques to produce pharmaceutically relevant spherical crystals.