Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Solid phase synthesis of combinatorial libraries using anhydrides as templates

J Perumattam1, S Chakravarty, G A McEnroe

  • 1Scios Inc., Sunnyvale, CA 94086, USA. perumattam@sciosinc.com

Molecular Diversity
|January 1, 1997
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Analysis of factors influencing the blood levels and activities of tissue-type plasminogen activator (t-PA).

Clinical hemorheology and microcirculation·2004
Same author

Major form of NUP98/HOXC11 fusion in adult AML with t(11;12)(p15;q13) translocation exhibits aberrant trans-regulatory activity.

Leukemia·2003
Same author

[Fluoride-oxide glass for high efficiency upconversion from IR to green].

Guang pu xue yu guang pu fen xi = Guang pu·2003
Same author

[In situ IR study of the reaction behavior of clusters [VnCr3-n (mu 3-O) (mu-O2CCH3)6(THF)3]X[n = 0-3, X = Cl-, ClO4-, (VO5)0.5-] and [VnFe3-n(mu 3-O) (mu-O2CCH3)6(THF)3]X(n = 0-3, X = Cl-) in nitrogen atmosphere].

Guang pu xue yu guang pu fen xi = Guang pu·2003
Same author

[In situ IR study of the reaction behavior of transition metal oxides-propionic acid system, Fe2Cr(mu 3-O) (mu-O2CC2H5)6(H2O)3Cl.xH2O and Cr3 (mu 3-O) (mu-O2CC2H5)6(H2O)3NO3.xH2O].

Guang pu xue yu guang pu fen xi = Guang pu·2003
Same author

[Monte Carlo simulation of FCS in a laser gradient field].

Guang pu xue yu guang pu fen xi = Guang pu·2003
Same journal

Discovery of novel cinnamic acid derivatives with anti-Helicobacter pylori mechanism.

Molecular diversity·2026
Same journal

Tetrapeptide inhibitors of BACE-1 revealed by combined data-driven screening and physics-based free-energy refinement.

Molecular diversity·2026
Same journal

A cheminformatics and DFT exploration of a brominated sulfonamide with nonlinear optical response and preliminary in silico bioactivity assessment.

Molecular diversity·2026
Same journal

Triazoles as enzyme inhibitors: synthetic advances, mechanism of action, molecular docking studies and structure-activity relationships.

Molecular diversity·2026
Same journal

Synthesis of 9H-furo[2,3-f]chromenes using multicomponent reactions of euparin: investigation of biological activity.

Molecular diversity·2026
Same journal

Discovery of novel perillyl and myrtenyl nucleobase conjugates as dual anti-Alzheimer and antimicrobial agents.

Molecular diversity·2026
See all related articles

A universal anhydride template enables rapid synthesis of diverse chemical libraries. This combinatorial approach efficiently generates numerous compounds using various amines.

Area of Science:

  • Organic Chemistry
  • Medicinal Chemistry
  • Combinatorial Chemistry

Background:

  • Chemical library synthesis is crucial for drug discovery and materials science.
  • Developing efficient and versatile synthetic methodologies remains a key challenge.

Purpose of the Study:

  • To present a simple, general, and efficient approach for synthesizing large chemical libraries.
  • To demonstrate the utility of a universal anhydride template in multi-component reactions.

Main Methods:

  • Utilizing a universal anhydride template for chemical synthesis.
  • Employing various cyclic/acyclic, primary/secondary, and protected bifunctional amines as nucleophiles.
  • Coupling the generated free carboxylic acid with solid-bound amines in a multi-component assembly.

Related Experiment Videos

Main Results:

  • Successful preparation of a large number of diverse compounds.
  • Demonstration of facile and rapid compound generation.
  • Adaptability to combinatorial parallel synthesis.

Conclusions:

  • The developed method provides a powerful tool for combinatorial library synthesis.
  • This approach offers a general and efficient route to access diverse chemical entities.
  • The strategy is suitable for high-throughput synthesis in drug discovery and chemical biology.