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Congenital esotropia in Olmsted County, Minnesota
B G Mohney1, J C Erie, D O Hodge
1Department of Ophthalmology, Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55905, USA.
Ophthalmology
|May 21, 1998
Summary
The birth prevalence of congenital esotropia is 27 per 10,000 live births. Key risk factors include prematurity, low birth weight, low Apgar scores, and family history of strabismus.
Area of Science:
- Ophthalmology
- Pediatrics
- Epidemiology
Background:
- Congenital esotropia is a common form of strabismus in children.
- Previous estimates of its prevalence vary, necessitating updated population-based data.
Purpose of the Study:
- To determine the birth prevalence of congenital esotropia.
- To identify associated risk factors in a defined population.
Main Methods:
- Population-based prevalence and nested case-control study in Olmsted County, Minnesota.
- Identified 47 cases born between 1980-1989 from 17,536 live births.
- Reviewed community medical records for case confirmation and risk factor ascertainment.
Main Results:
- The birth prevalence was 27 per 10,000 live births (95% CI, 20-35).
- Significant risk factors included prematurity (OR, 11.5), low birth weight <2500g (OR, 4.6), low Apgar scores at 1 and 5 minutes (ORs 4.3 and 6.3), and family history of strabismus (OR, 3.5).
Conclusions:
- The birth prevalence of congenital esotropia in this cohort is lower than previously reported.
- Prematurity, low birth weight, low Apgar scores, and family history of strabismus are confirmed significant risk factors.