[Therapeutic effect of THAM on lactic acidosis of severe brain injury]

The presence of lactic acidosis in the cerebral spinal fluid of 50 patients with severe head injury was studied. The GCS scores of these patients were < or = 8. The patients were divided into two groups. We treated 25 patients with a dose of 4 to 5 ml/kg of THAM infused intravenously 2 to 3 times for daily administration. Other 25 patients who were not treated with THAM served as a control group. In each case, a ventricular pressure monitoring device was installed. The ICP was the contineously recorded. In addition, laboratory study, including lactate, pH, HCO-3 and BE in CSF was performed. THAM infusion was associated with improved survival, decreased ICP as compared to that in the control group. We believe that THAM treatment may significantly improve the prognosis of presence of lactic acidosis as a result of severe head injury.