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Published on: September 13, 2014
[Gastric mucosal hemodynamics of prehepatic portal hypertensive rat model]
Objective:
To observe the changes of gastric mucosal hemodynamics and discuss the possible regulatory factors of prehepatic portal hypertensive rat.
Method:
Prehepatic portal hypertensive (PHT) rat model was produced by various degree of portal vein constriction, and gastric mucosal hemodynamics was measured by radioactive microsphere technique. Statistical analysis was performed by ANOVA, the student t test, and linear correlation.
Result:
The gastric mucosal blood flow was significantly reduced in PHT rats, whereas the blood flow in submucosa, muscular layer prominently increased. The resistance of mucosal vasculature was elevated in PHT rats, however, that of submucosa and muscular layer was decreased remarkably. There was a negative correlation between the gastric mucosal blood flow and portal pressure.
Conclusion:
The gastric mucosa of prehepatic portal hypertensive rat model is poorly perfused prominently. It may be due to the increased mucosal vascular resistance and elevated portal pressure.
