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Related Experiment Videos

Transcriptional regulation during B cell development

A Henderson1, K Calame

  • 1Department of Veterinary Science, Pennsylvania State University, University Park 16802, USA. KLC1@columbia.edu

Annual Review of Immunology
|May 23, 1998
PubMed
Summary

This review details molecular events in B cell development, focusing on transcription factors and gene expression changes. It explores how these regulate key processes like immunoglobulin gene recombination and mutation.

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Area of Science:

  • Immunology
  • Molecular Biology
  • Genetics

Background:

  • B cell development involves complex molecular events during primary and antigen-dependent stages.
  • Understanding these processes is crucial for insights into immune system function and dysfunction.

Purpose of the Study:

  • To review the roles of transcription factors and coactivators in B cell development.
  • To discuss transcriptional regulation in the context of key B cell genetic processes.

Main Methods:

  • Literature review of molecular events in B cell development.
  • Analysis of gene expression patterns and transcriptional regulation.
  • Focus on immunoglobulin gene V(D)J recombination, somatic hypermutation, and isotype switch recombination.

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Main Results:

  • Transcription factors and coactivators significantly influence gene expression during B cell development.
  • These regulatory elements are critical for developmentally programmed genetic events.
  • Specific examples of transcriptional regulation in V(D)J recombination, somatic hypermutation, and isotype switching are discussed.

Conclusions:

  • Transcription factors and coactivators are central regulators of B cell development.
  • Understanding transcriptional control is key to deciphering B cell genetic diversification and function.
  • This review consolidates current knowledge on molecular mechanisms governing B cell maturation.