Related Experiment Video
Updated: Jul 29, 2026
Engineering 3D Cellularized Collagen Gels for Vascular Tissue Regeneration
Published on: June 16, 2015
Autologous human collagen and dermal fibroblasts for soft tissue augmentation
1Washington Institute of Dermatologic Laser Surgery, DC, USA.
Background:
Augmentation of soft tissue defects can be achieved through intradermal injection of silicone, animal collagen, plasma-gelatin mixture, and fat. Due to their rapid degradation in vivo, however, clinical effects are typically transient. The use of autologous human collagen could conceivably result in sustained clinical improvement due to decreased collagen degradation.
Objective:
The purpose of this study was to determine whether prolonged dermal correction could be achieved through injection of autologous human fibroblasts.
Results:
Significant sustained clinical improvement was observed in two of the original 12 patients entered into the study. The nasolabial fold region was shown to be the most responsive facial area to treatment.
Conclusions:
The use of injectable autologous human collagen for soft tissue correction remains an intriguing prospect. While the findings of this study indicate possible sustained clinical improvement using this autologous system in some patients, it remains difficult to predict the degree and duration of individual response in various areas.
