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Severe neuropathy after high dose carboplatin in three patients receiving multidrug chemotherapy
O Heinzlef1, J P Lotz, E Roullet
1Department of Neurology, Hôpital Tenon, Paris, France. olivier.heinzlef@tnn.ap-hop-paris.fr
Journal of Neurology, Neurosurgery, and Psychiatry
|May 23, 1998
Abstract:
Three patients are described who developed a severe neuropathy after chemotherapy with high dose cis-diamine-(1,1-cyclobutane dicarboxylato) platinum (carboplatin). This toxic side effect, which is unusual at conventional doses, might become more frequent as increasing doses are administered to overcome drug resistance in cancer treatment, and might limit its use at very high doses before haematopoietic stem cell transplantation.