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Radiation therapy for uveal malignant melanoma
C L Shields1, J A Shields, K Gündüz
1Ocular Oncology Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, PA 19107, USA.
Ophthalmic Surgery and Lasers
|May 26, 1998
Summary
Uveal melanoma treatment involves eye removal or eye-sparing methods like plaque radiotherapy and charged particle radiotherapy, offering comparable outcomes. Thermotherapy is a key addition to radiotherapy for better uveal melanoma control.
Area of Science:
- Ophthalmology
- Oncology
Background:
- Uveal melanoma treatment remains a subject of debate.
- Various eye-preserving techniques exist alongside enucleation.
Purpose of the Study:
- To compare the efficacy and complications of different uveal melanoma treatments.
- To evaluate the role of emerging therapies like thermotherapy.
Main Methods:
- Review of treatment modalities for uveal melanoma.
- Comparison of outcomes including tumor control, patient survival, and complications.
- Assessment of plaque radiotherapy, charged particle radiotherapy, and thermotherapy.
Main Results:
- Plaque radiotherapy and charged particle radiotherapy demonstrate comparable tumor control and survival rates to enucleation.
- Plaque radiotherapy may result in fewer anterior segment complications.
- Posterior segment complications appear similar between plaque and charged particle radiotherapy.
- Thermotherapy shows promise as an adjuvant to radiotherapy for uveal melanoma management.
Conclusions:
- Eye-preserving radiotherapy techniques offer viable alternatives to enucleation for uveal melanoma.
- Thermotherapy is an important emerging adjuvant treatment for enhancing uveal melanoma control post-radiotherapy.