Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Alternative tests: carcinogenesis as an example

B Schwetz1, D Gaylor

  • 1U.S. Food and Drug Administration/National Center for Toxicological Research, Jefferson, Arkansas 72079-9502, USA. bschwetz@nctr.fda.gov

Environmental Health Perspectives
|May 26, 1998
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Report of an Expert Panel on the reanalysis by of a 90-day study conducted by Monsanto in support of the safety of a genetically modified corn variety (MON 863).

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association·2007
Same author

Threshold analysis of selected dose-response data for endocrine active chemicals.

APMIS : acta pathologica, microbiologica, et immunologica Scandinavica·2001
Same author

Rodent carcinogenicity studies on magnetic fields.

Toxicologic pathology·1999
Same author

Procedures for calculating benchmark doses for health risk assessment.

Regulatory toxicology and pharmacology : RTP·1999
Same author

No threshold dose for estradiol-induced sex reversal of turtle embryos: how little is too much?

Environmental health perspectives·1999
Same author

Use of Druckrey analysis to quantitatively evaluate the chemopreventive efficacy of N-difluoromethylornithine (DFMO), a prototype proliferation inhibitor.

Mutation research·1998
Same journal

A New Start.

Environmental health perspectives·2026
Same journal

Time-Varying Exposure to Element Mixtures and Children's Cognition at 5 Years of Age: Findings from the New Hampshire Birth Cohort Study.

Environmental health perspectives·2026
Same journal

Effect of Household Air Pollution on the Gut Microbiome and Virome of Adult Women Living in Uganda.

Environmental health perspectives·2026
Same journal

Comparison of Temperature-Mortality Associations across the Middle East Using Different Exposure Estimation Approaches.

Environmental health perspectives·2026
Same journal

Workflow for Statistical Analysis of Environmental Mixtures.

Environmental health perspectives·2026
Same journal

Effects of Extreme Heat Exposure on Heatstroke and Liver Injury in Mice: The Role of PPARα.

Environmental health perspectives·2026
See all related articles

New toxicology tests offer mechanistic insights, potentially replacing lengthy and expensive 2-year carcinogenicity studies in rodents. This shift aims for faster, data-driven decisions on carcinogenic potential.

Area of Science:

  • Toxicology
  • Regulatory Science
  • Biomedical Research

Background:

  • Current carcinogenicity testing relies on lengthy (5+ years), expensive 2-year rodent studies.
  • These studies, while providing tumor data, often lack mechanistic understanding.
  • Existing protocols involve genetic toxicity and subchronic studies to inform dose selection.

Purpose of the Study:

  • To explore the development and acceptance of alternative toxicology tests.
  • To provide more mechanistic information for carcinogenicity assessment.
  • To enable regulatory decisions based on data profiles rather than solely on 2-year rodent studies.

Main Methods:

  • Review of current carcinogenicity testing procedures.
  • Discussion of emerging alternative testing strategies.

Related Experiment Videos

  • Analysis of regulatory acceptance pathways for new toxicological assays.

    • Main Results:

    • Alternative approaches are under development to yield mechanistic data.
    • These methods aim to reduce reliance on traditional 2-year rodent bioassays.
    • A profile of data, rather than a single test, could inform decisions.

    Conclusions:

    • Alternative toxicology tests offer a path toward more efficient and informative carcinogenicity assessment.
    • Regulatory acceptance of these novel approaches is crucial for advancing the field.
    • Future progress depends on establishing clear procedures for validating and implementing new testing methods.