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The allopurinol hypersensitivity syndrome
H J Pluim1, M van Deuren, J F Wetzels
1Interne Geneeskunde, Canisius Wilhelmina Ziekenhuis, Nijmegen, Netherlands.
The Netherlands Journal of Medicine
|May 26, 1998
Abstract:
We describe a 61-year-old male patient who was treated with allopurinol and developed fever, a skin rash, eosinophilia and severe renal and liver dysfunction. We discuss the allopurinol hypersensitivity syndrome as a serious complication of the use of allopurinol, and briefly review the aetiology, prevention and treatment modalities.