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Updated: Aug 13, 2026

Flow Cytometry-based Purification of S. cerevisiae Zygotes
Published on: September 21, 2012
Multiple epigenetic events regulate mating-type switching of fission yeast
A J Klar1, A V Ivanova, J Z Dalgaard
1National Cancer Institute-Frederick Cancer Research, Frederick, MD 21702-1201, USA.
Abstract:
Two epigenetic events at mat1, one of which is DNA strand specific, are required to initiate recombination during mating-type switching. The third, a chromosomally borne imprinted event at the mat2/3 interval regulates silencing and directionality of switching, and prohibits interchromosomal recombination. We speculate that the unit of inheritance in the mat2/3 interval is both DNA plus its associated chromatin structure. Such a control is likely to be essential in maintaining particular states of gene expression during development.
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