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[IgD plasmacytoma--observations in 5 patients]

F Matĕja¹, M Tichý, M Zvarová

¹Hematologicko-transfuzní oddĕlení Orlické nemocnice.

Vnitrni Lekarstvi

|May 1, 1997

Summary

This study details five IgD plasmacytoma cases, noting rapid progression and Bence Jones protein in all patients. Diagnosis involved bone marrow, serum, urine tests, and skeletal X-rays, revealing osteolytic lesions and myeloma kidney.

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Area of Science:

Hematology
Oncology
Nephrology

Background:

Plasmacytoma IgD is a rare plasma cell neoplasm.
Understanding its clinical presentation and diagnostic challenges is crucial.

Observation:

Five cases of plasmacytoma IgD are presented, affecting both males and females across a range of ages.
All patients exhibited Bence Jones protein in urine, with light lambda or kappa chain involvement.
Diagnostic methods included bone marrow puncture, immunochemical analysis, and skeletal X-rays.

Findings:

Multiple osteolytic bone lesions and myeloma kidney were consistently observed.
Renal biopsy proved essential in two cases initially misdiagnosed as glomerulonephritis.
Three patients had extraosseous organ involvement, and one developed amyloidosis.

Implications:

Plasmacytoma IgD can present with aggressive clinical courses and rapid progression.
Early and accurate diagnosis, integrating various laboratory and imaging techniques, is vital.
This highlights the importance of considering rare plasma cell disorders in renal failure patients.

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