Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Immunologic reactions triggered during irritant contact dermatitis

B J Nickoloff1

  • 1Department of Pathology, Loyola University Medical Center, Maywood, IL 60153-5385, USA.

American Journal of Contact Dermatitis : Official Journal of the American Contact Dermatitis Society
|June 11, 1998
PubMed
Summary

This study explores how specialized proteins called cytokines impact human skin barrier function and immune responses. Understanding cytokine modulation offers new insights into skin

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The many molecular mysteries of melanoma.

Methods in molecular medicine·2012
Same author

2-deoxyglucose sensitizes melanoma cells to TRAIL-induced apoptosis which is reduced by mannose.

Biochemical and biophysical research communications·2010
Same author

Targeting glutamine metabolism sensitizes melanoma cells to TRAIL-induced death.

Biochemical and biophysical research communications·2010
Same author

3-Bromopyruvate induces necrotic cell death in sensitive melanoma cell lines.

Biochemical and biophysical research communications·2010
Same author

Notch-1 associates with IKKalpha and regulates IKK activity in cervical cancer cells.

Oncogene·2008
Same author

Claudin-1 overexpression in melanoma is regulated by PKC and contributes to melanoma cell motility.

Oncogene·2006

Area of Science:

  • Dermatology
  • Immunology
  • Biophysics

Background:

  • The skin's primary homeostatic function is regulating hydration via the stratum corneum.
  • Previous research focused on the biophysical properties and models (e.g., brick and mortar) of the skin barrier.
  • Limited focus has been placed on the role of specific proteins in barrier function.

Purpose of the Study:

  • To investigate a novel approach to understanding human skin barrier function.
  • To emphasize the immunologic consequences of skin barrier perturbation.
  • To characterize the role of cytokines in skin barrier structure and function.

Main Methods:

  • Characterization of specialized proteins (cytokines) linked to skin barrier structure and function.
  • Analysis of cytokine modulation in response to changes in barrier function.

Related Experiment Videos

  • Integration of biophysical and immunological perspectives on skin barrier function.

    • Main Results:

    • Cytokines are intimately linked to the barrier structure and function of human and rodent skin.
    • Cytokine modulation in response to barrier changes provides new insights.
    • The study moves beyond the physical/mechanical protective nature of skin into its immunologic sphere.

    Conclusions:

    • Cytokines are key mediators of inflammatory and immunologic reactions relevant to skin barrier function.
    • Understanding cytokine roles expands the concept of skin barrier function to include immunologic aspects.
    • This research offers new insights into cutaneous homeostasis and the immunologic influence of the skin barrier.