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Recombination-based mechanisms for somatic hypermutation

Q Kong1, R S Harris, N Maizels

  • 1Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut 06520-8114, USA.

Immunological Reviews
|May 29, 1998
PubMed
Summary
This summary is machine-generated.

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Experiments suggest that recombination-based mechanisms, similar to those in microbes like E. coli, may drive somatic hypermutation in mice. This could involve templated or non-templated mutations in immunoglobulin genes.

Area of Science:

  • Molecular Biology
  • Genetics
  • Immunology

Background:

  • Somatic hypermutation (SHM) is crucial for antibody diversity.
  • Mechanisms of SHM, particularly recombination-based pathways, are under investigation.
  • Conserved recombination and repair functions across species suggest microbial models may offer insights.

Purpose of the Study:

  • To review experiments testing recombination-based mechanisms for SHM in mice.
  • To explore the relevance of microbial mutation pathways to SHM.
  • To present a model for recombination-based hypermutation.

Main Methods:

  • Review of experimental data on SHM in mice.
  • Comparison of SHM with microbial mutation and repair pathways (e.g., E. coli, S. cerevisiae).

Related Experiment Videos

  • Development of a theoretical model for recombination-based hypermutation.

    • Main Results:

    • Recombination-based mechanisms, including templated mutation and gene conversion, are key areas of SHM research.
    • Microbial pathways like adaptive mutation in E. coli and double-strand break repair in S. cerevisiae share similarities with SHM.
    • A model is proposed where recombination at immunoglobulin loci can lead to templated or non-templated mutations.

    Conclusions:

    • Recombination plays a significant role in somatic hypermutation.
    • Microbial systems provide relevant models for understanding SHM mechanisms.
    • The proposed model offers a framework for templated and non-templated SHM via recombination.