Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Optimizing sound features for cortical neurons

R C deCharms1, D T Blake, M M Merzenich

  • 1Keck Center for Integrative Neuroscience, University of California, San Francisco, San Francisco, CA 94143-0732, USA.

Science (New York, N.Y.)
|June 20, 1998
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Modeling Intracochlear Magnetic Stimulation: A Finite-Element Analysis.

IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society·2016
Same author

Training sensory signal-to-noise resolution in children with ADHD in a global mental health setting.

Translational psychiatry·2016
Same author

Emergent categorical representation of natural, complex sounds resulting from the early post-natal sound environment.

Neuroscience·2013
Same author

Real-time fMRI neurofeedback: progress and challenges.

NeuroImage·2013
Same author

Influences of un-modulated acoustic inputs on functional maturation and critical-period plasticity of the primary auditory cortex.

Neuroscience·2008
Same author

Perinatal exposure to a noncoplanar polychlorinated biphenyl alters tonotopy, receptive fields, and plasticity in rat primary auditory cortex.

Proceedings of the National Academy of Sciences of the United States of America·2007
Same journal

A native sulfur deposit in Gale crater, Mars.

Science (New York, N.Y.)·2026
Same journal

Coordinated demise of harmful algal blooms.

Science (New York, N.Y.)·2026
Same journal

Genetic effects put into context.

Science (New York, N.Y.)·2026
Same journal

Bacteria share proteins to survive antibiotics.

Science (New York, N.Y.)·2026
Same journal

Impacts shaped Earth's first continents.

Science (New York, N.Y.)·2026
Same journal

Erratum for the Report "Covalently bonded single-molecule junctions with stable and reversible photoswitched conductivity" by C. Jia <i>et al</i>.

Science (New York, N.Y.)·2026
See all related articles

The auditory cortex breaks down sounds into basic features, similar to how the visual cortex processes images. This research reveals how auditory neurons detect specific sound characteristics like frequency and intensity changes.

Area of Science:

  • Neuroscience
  • Auditory Perception
  • Sensory Processing

Background:

  • The cerebral cortex decomposes visual input into features like edges, motion, and color.
  • The mechanisms by which the auditory cortex processes complex sounds remain less understood.
  • Investigating auditory cortical neuron selectivity is key to understanding sound perception.

Purpose of the Study:

  • To investigate how neurons in the primary auditory cortex (A1) of primates process complex sound features.
  • To determine if auditory processing shares principles with visual cortical processing.
  • To develop methods for efficiently probing auditory neuron feature selectivity.

Main Methods:

  • Utilized a reverse correlation technique to map sound-feature selectivity in auditory cortical neurons.

Related Experiment Videos

  • Designed specific stimuli to match the identified processing characteristics of individual neurons.
  • Recorded neuronal responses to both simple and custom-designed stimuli.

    • Main Results:

    • Auditory cortical neurons exhibit complex selectivity for sound features, including frequency/temporal edges and transitions.
    • Neurons respond to conjunctions of sound features.
    • Custom-designed stimuli effectively drove neurons with higher sustained firing rates compared to simple stimuli.

    Conclusions:

    • The auditory cortex decomposes auditory scenes into component features, analogous to visual cortical processing.
    • This feature-processing system in the auditory cortex is reminiscent of the visual system.
    • The findings provide insights into the neural basis of auditory scene analysis.