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Effect of fluticasone in severe polyposis
1Institute of Laryngology and Otology, Royal National Throat, Nose and Ear Hospital, London, England.
Archives of Otolaryngology--Head & Neck Surgery
|May 30, 1998
Summary
Intranasal corticosteroids like fluticasone and beclomethasone effectively treat severe nasal polyps, improving symptoms and nasal cavity volume. Fluticasone showed a quicker and greater response in this study.
Area of Science:
- Otolaryngology
- Allergy and Immunology
- Pharmacology
Background:
- Nasal polyps are inflammatory growths that can cause significant airway obstruction.
- Severe nasal polyposis often necessitates surgical intervention.
- Intranasal corticosteroids are a common treatment modality for nasal polyps.
Purpose of the Study:
- To evaluate the efficacy of intranasal corticosteroids in treating severe nasal polyps.
- To assess the impact of these treatments on disease progression in patients awaiting surgery.
- To compare the effects of fluticasone propionate aqueous nasal spray (FPANS) and beclomethasone dipropionate aqueous nasal spray.
Main Methods:
- A 12-week, double-blind, randomized, placebo-controlled study.
- Thirty-four patients with severe nasal polyps were randomized to receive FPANS, beclomethasone, or placebo nasal spray.
- Outcomes included polyp score, nasal cavity volume, peak nasal inspiratory flow, and symptom assessment.
Main Results:
- Both FPANS and beclomethasone significantly reduced polyp scores and increased nasal cavity volume compared to placebo.
- FPANS demonstrated a faster and more pronounced improvement in peak nasal inspiratory flow.
- Nasal blockage symptoms were significantly alleviated in both active treatment groups.
Conclusions:
- Fluticasone and beclomethasone aqueous nasal sprays are effective treatments for severe nasal polyps.
- FPANS may offer a more rapid and potent therapeutic effect.
- These corticosteroids can manage symptoms in patients with severe nasal polyps.
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