Effect of fluticasone in severe polyposis

Area of Science:

• Otolaryngology
• Allergy and Immunology
• Pharmacology

Background:

• Nasal polyps are inflammatory growths that can cause significant airway obstruction.
• Severe nasal polyposis often necessitates surgical intervention.
• Intranasal corticosteroids are a common treatment modality for nasal polyps.

Purpose of the Study:

• To evaluate the efficacy of intranasal corticosteroids in treating severe nasal polyps.
• To assess the impact of these treatments on disease progression in patients awaiting surgery.
• To compare the effects of fluticasone propionate aqueous nasal spray (FPANS) and beclomethasone dipropionate aqueous nasal spray.

Main Methods:

• A 12-week, double-blind, randomized, placebo-controlled study.
• Thirty-four patients with severe nasal polyps were randomized to receive FPANS, beclomethasone, or placebo nasal spray.
• Outcomes included polyp score, nasal cavity volume, peak nasal inspiratory flow, and symptom assessment.

Main Results:

• Both FPANS and beclomethasone significantly reduced polyp scores and increased nasal cavity volume compared to placebo.
• FPANS demonstrated a faster and more pronounced improvement in peak nasal inspiratory flow.
• Nasal blockage symptoms were significantly alleviated in both active treatment groups.

Conclusions:

• Fluticasone and beclomethasone aqueous nasal sprays are effective treatments for severe nasal polyps.
• FPANS may offer a more rapid and potent therapeutic effect.
• These corticosteroids can manage symptoms in patients with severe nasal polyps.