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Prevention of insulin-dependent diabetes mellitus 1998

P Pozzilli1

  • 1Libero Istituto Universitario, Campus Biomedico, Rome, Italy.

Diabetes/Metabolism Reviews
|May 30, 1998
PubMed

Insights

Preventing insulin-dependent diabetes mellitus (IDDM) is now possible through early intervention trials. Research focuses on immunotolerance and dietary changes to stop diabetes development in at-risk individuals.

Area of Science:

  • Immunology
  • Endocrinology
  • Preventive Medicine

Background:

  • Understanding the pathogenesis of insulin-dependent diabetes mellitus (IDDM) has advanced significantly.
  • This progress has enabled the initiation of the first disease prevention trials in susceptible individuals.

Purpose of the Study:

  • To evaluate the efficacy of different intervention strategies for preventing IDDM.
  • To explore primary prevention methods, including immunotolerance induction and dietary modifications.

Main Methods:

  • Two major clinical trials are currently underway, investigating nicotinamide and insulin therapies.
  • Pilot trials are exploring various approaches, with a focus on inducing immunotolerance.
  • Investigating the removal of diabetogenic components from cow's milk for primary prevention.

Main Results:

  • First results from the main nicotinamide and insulin trials are anticipated around the turn of the century.
  • Pilot trials are providing initial insights into the feasibility of different prevention strategies.
  • Ongoing research is laying the groundwork for larger, multicenter studies.

Conclusions:

  • The field of IDDM prevention is rapidly evolving.
  • Intervention strategies for IDDM prevention are expected to become more widely available to at-risk populations.
  • Future efforts will focus on refining and expanding primary and secondary prevention approaches for IDDM.

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