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A method for creating reversible ureteric obstruction in the primate

J P Evans1, G P Candy, M G Veller

  • 1Department of Urology, University of The Witwatersrand Faculty of Health Sciences, Parktown, Johannesburg, Republic of South Africa.

Journal of Medical Primatology
|May 30, 1998
PubMed
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Researchers developed a new surgical technique for reversible ureteric obstruction in primates. This method allows for studying the effects of temporary kidney obstruction on renal function, confirmed by renogram imaging.

Area of Science:

  • Urology
  • Surgical Innovation
  • Renal Physiology

Background:

  • Ureteral obstruction can lead to significant renal damage.
  • Studying reversible obstruction is crucial for understanding kidney recovery.
  • Existing models for studying ureteral obstruction have limitations.

Purpose of the Study:

  • To develop and validate a surgical technique for establishing reversible ureteric obstruction in primates.
  • To confirm the patency and reversibility of the obstruction using renogram studies.
  • To assess the suitability of this model for investigating the impact of temporary ureteric obstruction on renal function.

Main Methods:

  • A novel surgical technique was employed to induce complete ureteric occlusion in adult male primates.
  • Technetium-99m diethylenetriamine penta-acetate (99mTc-DTPA) renogram studies were performed before occlusion, during obstruction, and after reversal.

Related Experiment Videos

  • Intra-ureteric silastic tubes were used to prevent ureteric strictures post-reversal.

    • Main Results:

    • The surgical technique successfully established reversible ureteric obstruction, confirmed by renogram.
    • Recovery of renal activity was observed in obstructed kidneys after reversal in surviving animals.
    • Autopsies confirmed the patency of all previously occluded ureters, with no strictures observed when silastic tubes were used.
    • Seven out of ten primates survived the procedure and reversal.

    Conclusions:

    • A reliable surgical method for creating reversible ureteric obstruction in primates has been established.
    • This technique, validated by renogram and histological findings, is suitable for preclinical research on renal function under temporary obstruction.
    • The use of intra-ureteric silastic tubes effectively prevents ureteric strictures, ensuring successful reversal.